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Invitrogen
Pan-cadherin Polyclonal Antibody
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FIGURE: 1 / 9
Pan-cadherin Antibody (PA5-16766) in ICC/IF
Immunofluorescence analysis of Cadherin Pan was done on 70% confluent log phase PC-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Cadherin Pan Rabbit Polyclonal Antibody (Product # PA5-16766) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room... View More
Product Details
PA5-16766
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the C-terminus of chicken N-cadherin
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Storage conditions
4°C
Shipping conditions
Wet ice
RRID
Product Specific Information
PA5-16766 targets Cadherin Pan in IHC (P) and WB applications and shows reactivity with Bovine, Canine, Chicken, Human, mouse, Non-human primate, Rat, and Xenopus laevis samples. This antibody recognizes Cadherin E, N, P and R (Cadherin 1, 2, 3 and 4).
The PA5-16766 immunogen is a synthetic peptide from the C-terminus of chicken N-cadherin.
Target Information
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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