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Invitrogen
FEN1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17279
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids surrounding Lys313 of human FEN-1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 a protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNase IV; FEN1; hFEN-1; maturation factor-1; unnamed protein product
Gene Aliases: FEN-1; MF1; RAD2
UniProt ID: (Human) P39748, (Rat) Q5XIP6
Entrez Gene ID: (Human) 2237, (Mouse) 14156, (Rat) 84490
magnesium ion binding
DNA binding
damaged DNA binding
double-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
RNA-DNA hybrid ribonuclease activity
exonuclease activity
protein binding
double-stranded DNA exodeoxyribonuclease activity
5'-3' exonuclease activity
hydrolase activity, acting on ester bonds
5'-flap endonuclease activity
manganese ion binding
flap endonuclease activity
double-strand break repair via homologous recombination
DNA replication
DNA repair
base-excision repair
base-excision repair, gap-filling
double-strand break repair
DNA recombination
memory
UV protection
telomere maintenance via semi-conservative replication
DNA replication, removal of RNA primer
positive regulation of sister chromatid cohesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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