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Invitrogen
UBE2A/UBE2B Polyclonal Antibody
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Product Details
PA5-17592
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat,
Xenopus,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids at the amino-terminus of human HR6A
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2 protein; E2 ubiquitin-conjugating enzyme A; E2 ubiquitin-conjugating enzyme B; E2(14k); HHR6A (Human homologue of yeast RAD 6); putative; HHR6B (Human homologue of yeast RAD 6); putative; RAD6 homolog A; RAD6 homolog B; UBE2B; ubiquitin carrier protein A; ubiquitin carrier protein B; ubiquitin conjugating enzyme; ubiquitin conjugating enzyme E2B; ubiquitin-conjugating enzyme E2(14k); ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme E2B; ubiquitin-conjugating enzyme E2B (RAD6 homolog); ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homolog; ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-conjugating enzyme HR6A; ubiquitin-protein ligase A; ubiquitin-protein ligase B; unnamed protein product
Gene Aliases: E2-14k; E2-17kDa; E214K; HHR6A; HHR6B; HR6A; HR6B; Mhr6a; mHR6B; mp:zf637-2-000771; MRXS30; MRXSN; RAD6A; RAD6B; si:bz46j2.4; UBC2; wu:fa01h11; zgc:100921
UniProt ID: (Human) P49459, (Human) P63146, (Mouse) Q9Z255, (Mouse) P63147, (Rat) P63149
G2/M transition of mitotic cell cycle
protein polyubiquitination
in utero embryonic development
blastocyst hatching
DNA repair
chromatin remodeling
biological_process
response to UV
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
maternal process involved in female pregnancy
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of mitophagy
postreplication repair
chromatin organization
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
spermatogenesis
sperm axoneme assembly
response to xenobiotic stimulus
positive regulation of reciprocal meiotic recombination
negative regulation of apoptotic process
meiotic telomere clustering
protein stabilization
chiasma assembly
protein autoubiquitination
synaptonemal complex organization
protein K63-linked ubiquitination
positive regulation of canonical Wnt signaling pathway
negative regulation of post-translational protein modification
response to hypoxia
cellular response to insulin stimulus
histone ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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