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Invitrogen
Caspase 7 Polyclonal Antibody
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FIGURE: 1 / 3
Caspase 7 Antibody (PA5-17910) in WB
Western blot was performed using Anti-Caspase 7 Polyclonal Antibody (Product # PA5-17910) and a 35kDa band corresponding to Caspase-7 and a 20kDa band corresponding to the cleaved form of Caspase-7 (in Jurkat and HeLa) were observed upon Etoposide and Staurosporine treatment. An uncharacterized band around 65kDa was also observed in PC-12. Expression of Caspase-7 in Brain is low compared to Spleen. Whole cell extracts (30 µg lysate) of Jurkat (Lane 1), Jurkat treated with Etoposide (25uM for 16hr) (Lane 2), HeLa (Lane 3), HeLa treated with... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17910
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding the cleavage site of human caspase-7
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1071 µg/mL
Amount
107.1 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protease MCH-3; CASP-7; Casp7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; cysteine protease LICE2; ICE-like apoptotic protease 3; like-ICE cysteine protease; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6; similar to ICE and CED-3 cysteine protease; unnamed protein product
Gene Aliases: CASP-7; caspase-7; CMH-1; ICE-IAP3; ICE-LAP3; LICE2; mCASP-7; MCH3
UniProt ID: (Human) P55210, (Mouse) P97864
Entrez Gene ID: (Human) 840, (Rat) 64026, (Mouse) 12369
proteolysis
apoptotic process
axonal fasciculation
heart development
response to UV
response to ionizing radiation
protein processing
protein catabolic process
defense response to bacterium
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
animal organ development
striated muscle cell differentiation
neuron apoptotic process
protein maturation
lymphocyte apoptotic process
cellular response to lipopolysaccharide
leukocyte apoptotic process
cellular response to staurosporine
execution phase of apoptosis
positive regulation of plasma membrane repair
inflammatory response
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
plasma membrane repair
regulation of transcription from RNA polymerase II promoter
positive regulation of I-kappaB kinase/NF-kappaB signaling
ceramide biosynthetic process
protein poly-ADP-ribosylation
pyroptosis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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