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Invitrogen

ALOX5 Polyclonal Antibody

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ALOX5 Polyclonal Antibody

Product Details

PA5-18567

Applications
Tested Dilution
Publications

Western Blot (WB)

0.3-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (ERNKKKQLPYYYLSPD) corresponding to the C-terminus amino acids of ALOX5 (aa 651-666).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979140

Product Specific Information

This antibody is predicted to react with canine and mouse based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5 - Lipoxygenase; 5-lipoxygenase; 5-LO; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; lipoxygenase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3

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Gene Aliases: 5-LO; 5-LOX; 5LPG; ALOX5; LOG5; LOX5A

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UniProt ID: (Human) P09917, (Rat) P12527

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Entrez Gene ID: (Human) 240, (Rat) 25290

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Function(s)
arachidonate 5-lipoxygenase activity arachidonate 12-lipoxygenase activity iron ion binding protein binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen hydrolase activity arachidonate 8(S)-lipoxygenase activity metal ion binding dioxygenase activity oxygenase
Process(es)
long-chain fatty acid metabolic process negative regulation of endothelial cell proliferation leukocyte chemotaxis involved in inflammatory response leukocyte migration involved in inflammatory response leukotriene production involved in inflammatory response lipid metabolic process icosanoid metabolic process leukotriene metabolic process response to stress inflammatory response humoral immune response negative regulation of angiogenesis arachidonic acid metabolic process leukotriene biosynthetic process lipoxygenase pathway positive regulation of bone mineralization lipid oxidation dendritic cell migration glucose homeostasis long-chain fatty acid biosynthetic process regulation of fat cell differentiation regulation of inflammatory response negative regulation of inflammatory response regulation of insulin secretion negative regulation of vascular wound healing negative regulation of wound healing regulation of inflammatory response to wounding regulation of cytokine production involved in inflammatory response regulation of cellular response to oxidative stress leukotriene A4 biosynthetic process regulation of reactive oxygen species biosynthetic process negative regulation of response to endoplasmic reticulum stress negative regulation of sprouting angiogenesis positive regulation of leukocyte adhesion to arterial endothelial cell lipoxin biosynthetic process acute inflammatory response response to nutrient sensory perception of pain positive regulation of vasoconstriction response to hyperoxia oxidation-reduction process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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