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Invitrogen

PAX6 Polyclonal Antibody

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PAX6 Polyclonal Antibody

Product Details

PA5-18713

Applications
Tested Dilution
Publications

Western Blot (WB)

0.03-1 µg/mL
-

Flow Cytometry (Flow)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (REEKLRNQRRQASN) corresponding to the internal amino acids of PAX6 (aa 267-281).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982797

Product Specific Information

This antibody is predicted to react with human and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternative protein PAX6; Aniridia; Aniridia 1; Aniridia 2; aniridia type II protein; Dickie's small eye; driven by P1 promotor; Keratitis; MGC17209; oculorhombin; paired box 6 PAX6-12a isoform; paired box 6 PAX6A-ASdel6 isoform; paired box 6 PAX6A-ASdel6-AS7 isoform; paired box 6 PAX6A-del6 isoform; paired box 6 PAX6B-ASdel6 isoform; paired box 6 PAX6D isoform; paired box gene 6; Paired Box Gene-6; paired box homeotic gene-6; Pax-6 (paired box containing gene); Pax6; Pax6(S); encoded by transcript variant 4; unnamed protein product

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Gene Aliases: 1500038E17Rik; AEY11; AN; AN1; AN2; ASGD5; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; Sey; WAGR

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UniProt ID: (Human) P26367, (Mouse) P63015

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Entrez Gene ID: (Human) 5080, (Mouse) 18508

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding protein kinase binding chromatin DNA binding ubiquitin protein ligase binding histone acetyltransferase binding sequence-specific DNA binding co-SMAD binding R-SMAD binding HMG box domain binding sequence-specific double-stranded DNA binding AT DNA binding double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development eye development type B pancreatic cell differentiation pancreatic A cell development chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development central nervous system development brain development sensory organ development visual perception response to wounding anatomical structure morphogenesis organ morphogenesis positive regulation of gene expression ventral spinal cord development cerebral cortex development neuron differentiation forebrain development glucose homeostasis camera-type eye development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron fate commitment negative regulation of neurogenesis neurological system process retina development in camera-type eye iris morphogenesis cornea development in camera-type eye positive regulation of pri-miRNA transcription from RNA polymerase II promoter establishment of mitotic spindle orientation cell fate determination neural crest cell migration neuron migration negative regulation of protein phosphorylation positive regulation of neuroblast proliferation epithelial cell development lens development in camera-type eye regionalization pancreatic A cell differentiation smoothened signaling pathway axonogenesis axon guidance salivary gland morphogenesis negative regulation of cell proliferation regulation of asymmetric cell division dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation gene expression regulation of gene expression regulation of neuron projection development spinal cord development telencephalon development pallium development rhombomere morphogenesis olfactory bulb development oligodendrocyte cell fate specification cerebral cortex regionalization forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation telencephalon regionalization pituitary gland development habenula development interkinetic nuclear migration signal transduction involved in regulation of gene expression cell differentiation keratinocyte differentiation regulation of cell migration positive regulation of epithelial cell differentiation hindbrain development lacrimal gland development eye photoreceptor cell development positive regulation of cell fate specification cell fate commitment positive regulation of cell differentiation regulation of neuron differentiation negative regulation of neuron differentiation regulation of timing of cell differentiation embryonic camera-type eye morphogenesis astrocyte differentiation negative regulation of epithelial cell proliferation regulation of neurogenesis establishment of organelle localization olfactory bulb mitral cell layer development neural precursor cell proliferation learned vocalization behavior or vocal learning positive regulation of glutamatergic neuron differentiation insulin metabolic process sensory neuron migration cellular response to leukemia inhibitory factor negative regulation of neural precursor cell proliferation positive regulation of neuron migration
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