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Invitrogen
IREB2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19158
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (SIHYEGSEYKLSHGS) corresponding to the internal amino acids of IREB2 (aa 489-503).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ23381; IRE-BP 2; iron regulatory protein 2; unnamed protein product
Gene Aliases: ACO3; D9Ertd85e; IRE-BP 2; IRE-BP2; IRP2; IRP2AD; NDCAMA
UniProt ID: (Human) P48200, (Mouse) Q811J3, (Rat) Q62751
Entrez Gene ID: (Human) 3658, (Mouse) 64602, (Rat) 64831
regulation of translation
porphyrin-containing compound biosynthetic process
cellular iron ion homeostasis
post-embryonic development
response to iron(III) ion
regulation of gene expression
negative regulation of translation
osteoclast differentiation
erythrocyte homeostasis
intestinal absorption
multicellular organismal iron ion homeostasis
cellular response to iron(III) ion
cellular response to manganese ion
cellular response to epidermal growth factor stimulus
cellular response to hypoxia
cellular response to mercaptoethanol
mRNA stabilization
response to iron(II) ion
response to zinc ion
response to activity
response to retinoic acid
response to copper ion
cellular response to retinoic acid
response to kainic acid
response to hypobaric hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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