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Invitrogen

OCT4 Polyclonal Antibody

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OCT4 Polyclonal Antibody

Product Details

PA5-19307

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (DRPNAVKLEKVEP) corresponding to the internal amino acids of POU5F1 (aa 112-124).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980232

Product Specific Information

This antibody is predicted to react with rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-Oct; 4-Oct; DADB-104B20.2; gp-9; HGNC:9221; MGC22487; non-spliced variant; Oct-3/4; OCT4-B1; OCT4B-variant 2; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3; octamer-binding transcription factor 4 alternative; OTTHUMP00000221150; OTTHUMP00000221151; POU class 5 homeobox 1; POU domain transcription factor OCT4; pou-2; POU-type homeodomain-containing DNA-binding protein; pou2; transcriptional regulator

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Gene Aliases: NF-A3; Oct-3; Oct-3/4; Oct-4; OCT3; Oct3/4; OCT4; OCT4Borf1; OTF-3; Otf-4; OTF3; Otf3-rs7; Otf3g; OTF4

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UniProt ID: (Human) Q01860, (Mouse) P20263

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Entrez Gene ID: (Human) 5460, (Mouse) 18999

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding ubiquitin protein ligase binding miRNA binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding cytokine binding chromatin DNA binding POU domain binding HMG box domain binding histone H3K56ac reader activity DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter endodermal cell fate specification blastocyst development heart induction endodermal-mesodermal cell signaling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to wounding anatomical structure morphogenesis regulation of asymmetric cell division regulation of gene expression BMP signaling pathway somatic stem cell population maintenance positive regulation of transcription from RNA polymerase II promoter cell fate commitment involved in formation of primary germ layer cardiac cell fate determination positive regulation of canonical Wnt signaling pathway negative regulation of pri-miRNA transcription from RNA polymerase II promoter telomere maintenance mesodermal cell fate commitment endodermal cell fate commitment ectodermal cell fate commitment trophectodermal cell differentiation blastocyst growth chromatin organization transcription from RNA polymerase II promoter gene expression positive regulation of gene expression negative regulation of gene expression stem cell population maintenance cell differentiation intracellular receptor signaling pathway germ-line stem cell population maintenance response to retinoic acid response to cytokine cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of calcium ion-dependent exocytosis stem cell differentiation negative regulation of protein kinase B signaling positive regulation of transcription initiation from RNA polymerase II promoter response to benzoic acid cellular response to leukemia inhibitory factor
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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