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Invitrogen
F1A alpha Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19955
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide near the carboxy terminus of human F1A. The immunogen is located within the last 50 amino acids of F1A alpha.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blot applications, this antibody detects a band at ~70kDa. A suggested positive control is mouse liver tissue lysate.
PA5-19955 can be used with blocking peptide PEP-0080.
Target Information
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp451E0710; F1A; F1A-alpha; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; FEM1-beta; feminization 1 homolog b; feminization of XX and XO animals 1B; FIAA; KIAA0396; mt-Fem; similar to Caenorhabditis elegans FEM-1; similar to Caenorhabditis elegans FEM-1 sex-determination protein; unnamed protein product
Gene Aliases: F1A-ALPHA; F1AA; FEM1-beta; mKIAA0396; NEDBES
UniProt ID: (Human) Q9UK73, (Mouse) Q9Z2G0, (Rat) P0C6P7
Entrez Gene ID: (Human) 10116, (Mouse) 14155, (Rat) 315745
epithelial cell maturation
developmental process involved in reproduction
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of ubiquitin-protein transferase activity
branching involved in prostate gland morphogenesis
epithelial cell maturation involved in prostate gland development
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of DNA damage checkpoint
apoptotic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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