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Invitrogen
TEM5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid synthetic peptide near the center of human TEM5. The immunogen is located within amino acids 560-610 of TEM5.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat kidney tissue lysate.
PA5-20442 can be used with blocking peptide PEP-0559.
Predicted species reactivity based on immunogen sequence: Mouse: (85%).
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; G-protein coupled receptor 124; seven-pass transmembrane protein; tumor endothelial marker 5; unnamed protein product
Gene Aliases: GPR124; TEM5
UniProt ID: (Human) Q96PE1
Entrez Gene ID: (Human) 25960, (Rat) 100363275
sprouting angiogenesis
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
central nervous system development
endothelial cell migration
regulation of angiogenesis
regulation of chemotaxis
canonical Wnt signaling pathway
regulation of establishment of blood-brain barrier
positive regulation of canonical Wnt signaling pathway
angiogenesis
positive regulation of endothelial cell migration
negative regulation of vascular endothelial growth factor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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