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Invitrogen
EVER2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20527
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide from near the amino terminus of human EVER2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat thymus tissue lysate.
PA5-20527 can be used with blocking peptide PEP-0647.
Target Information
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; epidermodysplasia verruciformis protein 2 homolog; LEVER2; SEVER2; TMC8; transmembrane channel-like 8; unnamed protein product
Gene Aliases: EV2; EVER2; EVIN2; mFLJ00400
UniProt ID: (Human) Q8IU68, (Mouse) Q7TN58
Entrez Gene ID: (Human) 147138, (Rat) 688276, (Mouse) 217356
cellular zinc ion homeostasis
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of protein complex assembly
positive regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein stabilization
regulation of extrinsic apoptotic signaling pathway via death domain receptors
tumor necrosis factor-mediated signaling pathway
ion transmembrane transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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