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BMPR2 Polyclonal Antibody
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FIGURE: 1 / 6
BMPR2 Antibody (PA5-21437) in WB
Western blot was performed using Anti-BMPR2 Polyclonal Antibody (Product # PA5-21437) and a 115 kDa band corresponding to BMPR2 was observed across the cell lines and tissues tested. Whole cell extracts (30 µg lysate) of HUV-EC-C (Lane 1), U-2 OS (Lane 2), tissue extracts (30 µg lysate) of Mouse Brain (Lane 3) and Rat Brain (Lane 4) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (P... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-21437
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of human BMPR2. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.17 mg/mL
Amount
17 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HUVEC.
Predicted reactivity: Mouse (92%), Rat (92%), Pig (92%), Chicken (86%), Sheep (93%), Rhesus Monkey (98%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMP-2/4 type II receptor; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); Ser/Thr kinase receptor; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4; unnamed protein product
Gene Aliases: 2610024H22Rik; BMP-2; BMPR-2; BMPR-II; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK
UniProt ID: (Human) Q13873, (Mouse) O35607
Entrez Gene ID: (Human) 659, (Mouse) 12168, (Rat) 140590
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
protein binding
ATP binding
activin receptor activity, type II
BMP binding
cadherin binding
BMP receptor activity
protein tyrosine kinase binding
growth factor binding
nucleotide binding
angiogenesis
regulation of cell growth
blood vessel development
osteoblast differentiation
mesoderm formation
cell fate specification
maternal placenta development
endothelial cell proliferation
vasculature development
lymphangiogenesis
blood vessel remodeling
chondrocyte development
negative regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
outflow tract morphogenesis
aortic valve development
pulmonary valve development
atrioventricular valve morphogenesis
mitral valve morphogenesis
tricuspid valve morphogenesis
endocardial cushion development
transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell proliferation
cellular response to starvation
tissue development
anterior/posterior pattern specification
positive regulation of gene expression
positive regulation of epithelial cell migration
regulation of lung blood pressure
cell differentiation
proteoglycan biosynthetic process
negative regulation of cell growth
lung development
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
positive regulation of locomotion
regulation of cell proliferation
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of vasoconstriction
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
negative regulation of smooth muscle cell proliferation
cardiac muscle tissue development
positive regulation of axon extension involved in axon guidance
stem cell differentiation
limb development
endochondral bone morphogenesis
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
atrial septum morphogenesis
lung vasculature development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
positive regulation of cartilage development
retina vasculature development in camera-type eye
pharyngeal arch artery morphogenesis
cellular response to growth factor stimulus
cellular response to BMP stimulus
endothelial cell apoptotic process
negative regulation of chondrocyte proliferation
semi-lunar valve development
regulation of multicellular organismal development
negative regulation of cell proliferation involved in heart morphogenesis
retina development in camera-type eye
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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