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Invitrogen
GBP5 Polyclonal Antibody
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FIGURE: 1 / 2
GBP5 Antibody (PA5-21809) in WB
Western Blot using GBP5 Polyclonal Antibody (Product # PA5-21809). Untreated (–) and treated (+) Raw264.7 whole cell extracts (30 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with GBP5 Polyclonal Antibody (Product # PA5-21809) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-21809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human GBP5. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T.
Predicted reactivity: Mouse (80%), Rat (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GBP-5; GBP-TA antigen; GBP5; Gbp5a; GTP-binding protein 5; guanine nucleotide-binding protein 5; guanylate nucleotide binding protein 5; muGBP-5; tumor-specific antigen of cutaneous T-cell lymphoma; unnamed protein product
Gene Aliases: 5330409J06Rik; GBP-5; Gbp5a
UniProt ID: (Human) Q96PP8, (Mouse) Q8CFB4
Entrez Gene ID: (Human) 115362, (Mouse) 229898
activation of innate immune response
protein targeting
response to bacterium
regulation of defense response
positive regulation of interleukin-1 beta production
positive regulation of interleukin-18 production
protein localization to Golgi apparatus
defense response to bacterium
positive regulation of innate immune response
viral entry into host cell
protein homotetramerization
protein maturation
defense response to virus
cytolysis in other organism
cellular response to lipopolysaccharide
cellular response to interferon-gamma
positive regulation of pyroptotic inflammatory response
positive regulation of AIM2 inflammasome complex assembly
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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