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Invitrogen

ATM Polyclonal Antibody, DyLight™ 488

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ATM Polyclonal Antibody, DyLight™ 488

Product Details

PA5-22690

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

Assay-Dependent
-

ELISA (ELISA)

Assay-Dependent
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Dog, Human, Marsupial, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A fragment of the human ATM protein corresponding to the C-terminus (within the last third of the protein sequence).
3D Epitope / Immunogen

Conjugate

DyLight™ 488 DyLight™ 488 DyLight™ 488

Excitation/Emission Max

492/519 nm View spectra spectra

Form

Liquid

Concentration

0.88 mg/mL

Amount

44 µg

Purification

Antigen affinity chromatography

Storage buffer

50mM sodium borate

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152836

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM's C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A-T; A-T mutated; A-T mutated homolog; AT mutated; AT mutated protein; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; ataxia telangiectasia mutated (includes complementation groups A, C and D); ataxia telangiectasia mutated homolog; DKFZp781A0353; EC 2.7.1.37; homolog of the human ataxia telangiectasia gene; MGC74674; mutated in ataxia telangiectasia; serine/threonine kinase ATM; TEL1, telomere maintenance 1, homolog; unnamed protein product

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Gene Aliases: AT1; ATA; ATC; ATD; ATDC; ATE; C030026E19Rik; TEL1; TELO1

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UniProt ID: (Human) Q13315, (Mouse) Q62388

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Entrez Gene ID: (Dog) 479450, (Human) 472, (Mouse) 11920, (Rat) 300711

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Function(s)
protein kinase activity protein serine/threonine kinase activity DNA-dependent protein kinase activity protein binding kinase activity 1-phosphatidylinositol-3-kinase activity histone H2AXS139 kinase activity identical protein binding macromolecular complex binding protein serine kinase activity non-receptor serine/threonine protein kinase
Process(es)
DNA damage checkpoint pexophagy telomere maintenance double-strand break repair via homologous recombination DNA double-strand break processing pre-B cell allelic exclusion DNA repair double-strand break repair double-strand break repair via nonhomologous end joining chromatin remodeling cellular response to DNA damage stimulus response to oxidative stress mitotic spindle assembly checkpoint mitotic G2 DNA damage checkpoint meiosis I reciprocal meiotic recombination signal transduction intrinsic apoptotic signaling pathway in response to DNA damage response to ionizing radiation regulation of gene expression regulation of autophagy positive regulation of gene expression DNA damage response, signal transduction by p53 class mediator positive regulation of cell migration negative regulation of B cell proliferation regulation of telomere maintenance via telomerase positive regulation of telomere maintenance via telomerase cellular response to stress cellular response to reactive oxygen species phosphatidylinositol-3-phosphate biosynthetic process peptidyl-serine autophosphorylation response to starvation signal transduction in response to DNA damage regulation of apoptotic process positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation protein stabilization regulation of cell cycle histone mRNA catabolic process cellular response to retinoic acid cellular response to gamma radiation cellular response to X-ray cellular response to nitrosative stress regulation of cellular response to stress cellular senescence replicative senescence establishment of RNA localization to telomere establishment of macromolecular complex localization to telomere regulation of cellular response to heat cellular response to oxygen-containing compound regulation of signal transduction by p53 class mediator negative regulation of TORC1 signaling negative regulation of telomere capping positive regulation of telomere maintenance via telomere lengthening positive regulation of telomerase catalytic core complex assembly positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair regulation of autophagosome assembly positive regulation of autophagosome assembly autophagosome assembly ovarian follicle development response to hypoxia somitogenesis immune system process protein phosphorylation protein monoubiquitination male meiosis female meiotic division female gamete generation brain development heart development determination of adult lifespan female gonad development post-embryonic development SCF-dependent proteasomal ubiquitin-dependent protein catabolic process V(D)J recombination multicellular organism growth lipoprotein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process meiotic telomere clustering thymus development oocyte development neuron apoptotic process chromosome organization involved in meiotic cell cycle protein K63-linked ubiquitination cellular response to ionizing radiation DNA strand resection involved in replication fork processing negative regulation of signal transduction by p53 class mediator positive regulation of DNA catabolic process regulation of microglial cell activation protein localization to site of double-strand break negative regulation of double-strand break repair via homologous recombination
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