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Invitrogen
TRPM2 Polyclonal Antibody, DyLight™ 488
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Product Details
PA5-22878
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to a C-terminal portion of the rat TRPM2 protein (within residues 1430-1507).
Conjugate
DyLight™ 488
DyLight™ 488
DyLight™ 488
Excitation/Emission Max
492/519 nm
View spectra
Form
Liquid
Concentration
1.25 mg/mL
Amount
125 µg
Purification
Antigen affinity chromatography
Storage buffer
50mM sodium borate
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.6.1.13; EREG 1; KNP 3; long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; transient receptor potential channel 7; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TRPM 2; unnamed protein product
Gene Aliases: 9830168K16Rik; LTRPC2; Trp7; TRPC7; Trpm2-predicted; Trrp7
UniProt ID: (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Rat) 294329, (Mouse) 28240
temperature homeostasis
dendritic cell chemotaxis
ion transport
manganese ion transport
response to heat
response to purine-containing compound
calcium-mediated signaling
positive regulation of insulin secretion
regulation of actin cytoskeleton organization
response to hydroperoxide
estrous cycle
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of filopodium assembly
transmembrane transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to calcium ion
manganese ion transmembrane transport
cellular response to temperature stimulus
zinc II ion transmembrane transport
dendritic cell differentiation
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
positive regulation of cellular response to oxidative stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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