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Invitrogen

SMAD7 Polyclonal Antibody

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SMAD7 Polyclonal Antibody

Product Details

PA5-23118

Applications
Tested Dilution
Publications

Western Blot (WB)

2-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL
-

Immunoprecipitation (IP)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Two peptides made from within amino acids 10 and 50 of human SMAD7.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540645

Target Information

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD5, SMAD8 and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16482; hSMAD7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; MAD homolog 8; madh8; mothers against decapentaplegic homolog 7; mothers against decapentaplegic homolog 8; Mothers against decapentaplegic, drosophila, homolog of, 7; mothers against DPP homolog 7; mothers against DPP homolog 8; SMAD; SMAD 7; SMAD, mothers against DPP homolog 7; unnamed protein product

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Gene Aliases: CRCS3; MADH7; MADH8

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UniProt ID: (Human) O15105, (Mouse) O35253

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Entrez Gene ID: (Sheep) 101111414, (Human) 4092, (Mouse) 17131

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Function(s)
transcription corepressor activity protein binding collagen binding beta-catenin binding ubiquitin protein ligase binding type I transforming growth factor beta receptor binding I-SMAD binding activin receptor binding transcription regulator inhibitor activity protein binding, bridging involved in substrate recognition for ubiquitination DNA-binding transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development negative regulation of T cell cytokine production regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway anatomical structure morphogenesis regulation of epithelial to mesenchymal transition negative regulation of epithelial to mesenchymal transition regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of ossification negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein complex localization positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of activin receptor signaling pathway protein-containing complex disassembly adherens junction assembly response to laminar fluid shear stress negative regulation of cell differentiation artery morphogenesis protein stabilization ventricular cardiac muscle tissue morphogenesis regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane depolarization negative regulation of SMAD protein import into nucleus SMAD protein signal transduction ventricular septum morphogenesis cellular response to growth factor stimulus transforming growth factor beta receptor superfamily signaling pathway negative regulation of chondrocyte proliferation positive regulation of chondrocyte hypertrophy beta-catenin destruction complex disassembly positive regulation of cell-cell adhesion mediated by cadherin negative regulation of T-helper 17 type immune response negative regulation of T-helper 17 cell differentiation intracellular signal transduction cellular response to leukemia inhibitory factor
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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