Search
Invitrogen
EPM2A Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
EPM2A Antibody (PA5-23252) in IHC (P)
Immunohistochemistry analysis of EPM2A in formalin-fixed, paraffin-embedded human heart. Samples were incubated with EPM2A polyclonal antibody (Product # PA5-23252) using a dilution of 10 µg/mL. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Product Details
PA5-23252
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 80-130 of human Laforin/EPM2A.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence homology: Zebrafish (87%).
Target Information
The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: dual-specificity phosphatase; epilepsy, progressive myoclonus type 2, Lafora disease (laforin); epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); EPM2A, laforin glucan phosphatase; Glucan phosphatase; Glycogen phosphatase; Lafora PTPase; Laforin; LAFPTPase; RP1-28C20.2; unnamed protein product
Gene Aliases: EPM2; EPM2A; laforin; MELF; MELF2
UniProt ID: (Human) O95278
Entrez Gene ID: (Human) 7957, (Bovine) 526888
glycogen (starch) synthase activity
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
hydrolase activity
phosphatase activity
carbohydrate phosphatase activity
carbohydrate binding
polysaccharide binding
identical protein binding
protein homodimerization activity
protein dimerization activity
glycogen binding
starch binding
autophagosome assembly
regulation of cell growth
glycogen metabolic process
glycogen biosynthetic process
protein dephosphorylation
phosphate-containing compound metabolic process
calcium ion transport
autophagy
mitochondrion organization
nervous system development
negative regulation of metabolic process
regulation of gene expression
negative regulation of gene expression
negative regulation of phosphatase activity
glial cell proliferation
L-glutamate transport
Wnt signaling pathway
positive regulation of macroautophagy
dephosphorylation
regulation of protein ubiquitination
negative regulation of TOR signaling
negative regulation of dephosphorylation
peptidyl-tyrosine dephosphorylation
regulation of protein import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle
carbohydrate phosphorylation
habituation
regulation of proteasomal protein catabolic process
regulation of protein localization to plasma membrane
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support