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Invitrogen
NALP10 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-23311
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 493-509 of human NALP10 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 95% homologous in rabbit and 86% homologous in mouse.
Immunogen sequence: REVQRLLEVK EQEGNDE
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1-like protein; pyrin-like domain- and nucleotide-binding and oligomerization domain-containing protein; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; unnamed protein product
Gene Aliases: 6430548I20Rik; CLR11.1; NALP10; Napl10; NOD8; PAN5; PYNOD
UniProt ID: (Human) Q86W26, (Mouse) Q8CCN1
Entrez Gene ID: (Human) 338322, (Mouse) 244202
activation of innate immune response
positive regulation of T-helper 1 type immune response
defense response
positive regulation of defense response
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of immune response
defense response to fungus
positive regulation of defense response to bacterium
positive regulation of T-helper 17 type immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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