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Invitrogen
SOX1 Polyclonal Antibody
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FIGURE: 1 / 2
SOX1 Antibody (PA5-23351) in WB
Western blot analysis of SOX1 in D3 cell lysate in the 1) absence and 2) presence of immunizing peptide. Samples were incubated in SOX1 polyclonal antibody (Product # PA5-23351) using a dilution of 1 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
Product Details
PA5-23351
Product Specifications
Species Reactivity
Horse,
Human,
Marsupial,
Mouse,
Non-human primate,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 100-150 of human SOX1.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sex determining region Y-box 1; sox1; SRY (Sex determining region Y)-box 1; SRY-box 1; SRY-box containing gene 1; SRY-box containing protein; SRY-related HMG-box gene 1; Transcription factor SOX-1; xlSox1
Gene Aliases: BB176347; Sox-1; SOX1; XELAEV_18015596mg; XlSox1; XSox1
UniProt ID: (Human) O00570, (Mouse) P53783, (Western clawed frog) A2TED3
Entrez Gene ID: (Human) 6656, (Mouse) 20664, (Western clawed frog) 779569, (Xenopus) 734174
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
HMG box transcription factor
negative regulation of transcription from RNA polymerase II promoter
neuron migration
lens morphogenesis in camera-type eye
chromatin organization
regulation of transcription, DNA-templated
brain development
ventral spinal cord interneuron specification
forebrain neuron differentiation
forebrain neuron development
neuron differentiation
forebrain development
positive regulation of transcription from RNA polymerase II promoter
regulation of oligodendrocyte differentiation
interneuron migration
cellular response to leukemia inhibitory factor
transcription, DNA-templated
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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