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Invitrogen

RAGE Polyclonal Antibody

1 Published Figure
5 References
View all (30) RAGE antibodies

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RAGE Polyclonal Antibody

Product Details

PA5-24787

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Flow Cytometry (Flow)

1:10-1:50
View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human AGER
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

200 µg

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2542287

Target Information

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-beta peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-kB activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: advanced glycation end-products receptor; advanced glycosylation end product receptor; Advanced glycosylation end product-specific receptor; RAGE-4 ORF3; RAGEdelex2-6; RAGEdelex3; RAGEdelex3-10; RAGEdelex3-7; RAGEdelex8&int9; RAGEint4; RAGEint4&9; RAGEint9&delex11; RAGEv1; RAGEv8; receptor for advanced glycation end-products; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; soluble receptor; sRAGE; unnamed protein product

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Gene Aliases: AGER; RAGE; SCARJ1; sRAGE

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UniProt ID: (Human) Q15109, (Mouse) Q62151

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Entrez Gene ID: (Human) 177, (Mouse) 11596

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Function(s)
beta-amyloid binding DNA binding RNA binding transmembrane signaling receptor activity scavenger receptor activity laminin receptor activity protein binding signaling receptor activity histone binding identical protein binding S100 protein binding macromolecular complex binding advanced glycation end-product receptor activity binding, bridging high mobility group box 1 binding cell adhesion molecule immunoglobulin superfamily cell adhesion molecule
Process(es)
response to hypoxia microglial cell activation positive regulation of cytokine production regulation of T cell mediated cytotoxicity DNA replication DNA repair phagocytosis inflammatory response cellular response to DNA damage stimulus cell adhesion cell surface receptor signaling pathway learning or memory positive regulation of cell proliferation response to wounding negative regulation of biosynthetic process glucose mediated signaling pathway astrocyte development regulation of cell adhesion positive regulation of cell migration neuron projection development negative regulation of interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of heterotypic cell-cell adhesion positive regulation of activated T cell proliferation transcytosis positive regulation of cell differentiation positive regulation of JNK cascade astrocyte activation regulation of synaptic plasticity regulation of inflammatory response induction of positive chemotaxis positive regulation of DNA metabolic process positive regulation of NF-kappaB transcription factor activity negative regulation of multicellular organismal process positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus positive regulation of monocyte chemotactic protein-1 production protein localization to membrane regulation of spontaneous synaptic transmission transport across blood-brain barrier regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin production negative regulation of connective tissue replacement involved in inflammatory response wound healing response to amyloid-beta cellular response to beta-amyloid positive regulation of DNA-dependent DNA replication positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of double-strand break repair positive regulation of dendritic cell differentiation negative regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation negative regulation of cell adhesion JAK-STAT cascade positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration positive regulation of smooth muscle cell migration negative regulation of collagen biosynthetic process positive regulation of apoptotic process positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of DNA binding calcium ion homeostasis positive regulation of phagocytosis, engulfment positive regulation of potassium ion transmembrane transporter activity positive regulation of neuron death positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process positive regulation of type B pancreatic cell apoptotic process
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