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Invitrogen
HAMP Polyclonal Antibody
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FIGURE: 1 / 2
HAMP Antibody (PA5-26470) in WB
Western blot analysis of HAMP in human liver lysate. Samples were incubated with HAMP polyclonal antibody (Product # PA5-26470) using a dilution of 1:500 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 9 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-26470
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 17-46 amino acids from the central region of human HAMP
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antimicrobial peptide precursor; Hepcidin; hepcidin preproprotein; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
Gene Aliases: HAMP; HEPC; HFE2B; LEAP1; PLTR; UNQ487/PRO1003
UniProt ID: (Human) P81172
Entrez Gene ID: (Human) 57817
negative regulation of transcription from RNA polymerase II promoter
positive regulation of receptor internalization
cellular iron ion homeostasis
immune response
signal transduction
response to iron ion
killing of cells of other organism
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of iron ion transmembrane transport
defense response to bacterium
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
cation homeostasis
multicellular organismal iron ion homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
inorganic ion homeostasis
positive regulation of protein polyubiquitination
ferrous iron export
negative regulation of iron export across plasma membrane
negative regulation of intestinal absorption
positive regulation of receptor catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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