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Invitrogen

CBP Polyclonal Antibody

Advanced Verification
4 Published Figures
10 References
View all (18) CBP antibodies

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CBP Polyclonal Antibody

Product Details

PA5-27369

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
View 1 publication 1 publication

Immunoprecipitation (IP)

1:100-1:500
View 2 publications 2 publications

ChIP assay (ChIP)

2.5 µg/10^6 cells
View 4 publications 4 publications
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human CBP. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.6 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544845

Product Specific Information

Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, HCT-116, Vero E6.

Predicted reactivity: Mouse (94%), Rat (94%), Rhesus Monkey (100%), Bovine (93%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CBP for CREB-binding protein is a 265 kDa nuclear protein which probably has many of the properties expected of a CREB co-activator. It shows substantial sequence homology with p300.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CBP/p300; CBP; CREBBP; CREBBP; histone lysine acetyltransferase CREBBP; KAT3A; protein lactyltransferas CREBBP; protein-lysine acetyltransferase CREBBP; RSTS; unnamed protein product

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Gene Aliases: CBP; CBP/p300; KAT3A; MKHK1; p300/CBP; RSTS; RSTS1

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UniProt ID: (Human) Q92793

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Entrez Gene ID: (Human) 1387, (Mouse) 12914

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Function(s)
transcription coactivator binding p53 binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity histone acetyltransferase activity protein binding zinc ion binding acetyltransferase activity chromatin DNA binding MRF binding histone acetyltransferase activity (H3-K18 specific) histone acetyltransferase activity (H3-K27 specific) tau protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding peptide-lysine-N-acetyltransferase activity peptide lactyltransferase (CoA-dependent) activity DNA-binding transcription factor binding RNA polymerase II regulatory region sequence-specific DNA binding TFIIB-class transcription factor binding DNA binding cAMP response element binding protein binding protein domain specific binding peroxisome proliferator activated receptor binding macromolecular complex binding SMAD binding binding, bridging disordered domain specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia stimulatory C-type lectin receptor signaling pathway chromatin remodeling regulation of transcription, DNA-templated I-kappaB kinase/NF-kappaB signaling regulation of smoothened signaling pathway negative regulation of transcription from RNA polymerase I promoter positive regulation of transforming growth factor beta receptor signaling pathway protein destabilization cellular response to nutrient levels cellular response to UV embryonic digit morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein-containing complex assembly cAMP/PKA signal transduction regulation of cellular response to heat positive regulation of protein localization to nucleus negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of double-strand break repair via homologous recombination regulation of nucleotide-excision repair double-strand break repair via homologous recombination regulation of transcription from RNA polymerase II promoter protein acetylation long-term memory positive regulation of gene expression N-terminal peptidyl-lysine acetylation germ-line stem cell population maintenance negative regulation of interferon-beta production cellular response to hepatocyte growth factor stimulus behavioral response to cocaine negative regulation of viral process protein stabilization face morphogenesis positive regulation of cell adhesion molecule production positive regulation of dendritic spine development protein K48-linked deubiquitination energy homeostasis cellular response to virus positive regulation of G1/S transition of mitotic cell cycle positive regulation of NIK/NF-kappaB signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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