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Invitrogen

TGM2 Polyclonal Antibody

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View all (47) TGM2 antibodies

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Product Details

PA5-29356

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Transglutaminase 2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546832

Product Specific Information

Recommended positive controls: A549.

Predicted reactivity: Mouse (87%), Rat (86%), Bovine (87%), Guinea pig (85%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; crosslinker; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG; tTgase; unnamed protein product

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Gene Aliases: G(h); G[a]h; hTG2; TG(C); TG2; TGase2; TGC; TGM2; tTG; tTGas

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UniProt ID: (Human) P21980, (Mouse) P21981

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Entrez Gene ID: (Human) 7052, (Mouse) 21817

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Function(s)
nucleotide binding protein-glutamine gamma-glutamyltransferase activity calcium ion binding protein binding GTP binding peptidase activity transferase activity transferase activity, transferring acyl groups hydrolase activity metal ion binding protein-glutamine glutaminase activity peptide serotonyltransferase activity histone serotonyltransferase activity peptide dopaminyltransferase activity histone dopaminyltransferase activity peptide noradrenalinyltransferase activity peptide histaminyltransferase activity transaminase activity protein domain specific binding transferase
Process(es)
chromatin remodeling proteolysis phospholipase C-activating G-protein coupled receptor signaling pathway gene expression dopamine secretion peptide cross-linking protein deamination negative regulation of endoplasmic reticulum calcium ion concentration regulation of apoptotic process positive regulation of apoptotic process apoptotic cell clearance positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of neurogenesis positive regulation of small GTPase mediated signal transduction protein homooligomerization positive regulation of mitochondrial calcium ion concentration bone development branching involved in salivary gland morphogenesis salivary gland cavitation cellular response to cocaine cellular response to dopamine positive regulation of sprouting angiogenesis cellular response to serotonin regulation of apoptotic cell clearance blood vessel remodeling G-protein coupled receptor signaling pathway isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
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