Search
Invitrogen
SUV39H1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
SUV39H1 Antibody (PA5-29470) in ICC/IF
Immunofluorescent analysis of SUV39H1 (green) in human hepatocytes. The cells were fixed, permeabilized and blocked. Cells were stained with a SUV39H1 polyclonal antibody (Product # PA5-29470) at a dilution of 1:500, followed by staining with Alexa fluor 488 goat anti-rabbit secondary antibody (Product # A-11008) at a dilution of 1:500 (green). Nuclei (blue) were counterstained with DAPI. Images were taken at 50X magnification. Data courtesy of the Antibody Data Exchange Program.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-29470
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SUV39H1. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.52 mg/mL
Amount
52 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, H1299, Raji, Mouse brain.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (90%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; located at OATL1; lysine N-methyltransferase 1A; position-effect variegation 3-9 homolog; pSUV39H; pSuvar39h; Su(var)3-9 homolog 1; suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase; SUV39H1; unnamed protein product
Gene Aliases: DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; SUV39H
UniProt ID: (Human) O43463, (Mouse) O54864
Entrez Gene ID: (Human) 6839, (Mouse) 20937
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
protein binding
zinc ion binding
S-adenosylmethionine-dependent methyltransferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K9 specific)
histone H3K14ub reader activity
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 trimethyltransferase activity
protein methyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
blastocyst hatching
regulation of DNA repair
cellular response to DNA damage stimulus
circadian rhythm
determination of adult lifespan
regulation of bone mineralization
heterochromatin assembly
pericentric heterochromatin assembly
regulation of multicellular organism growth
cellular response to glucose starvation
epigenetic programming in the zygotic pronuclei
negative regulation of cell cycle
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
regulation of transcription by glucose
chromosome organization
heterochromatin organization
cellular response to hypoxia
energy homeostasis
regulation of cellular senescence
chromatin organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support