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Invitrogen

MyD88 Polyclonal Antibody

1 Reference
View all (33) MyD88 antibodies

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Product Details

PA5-29611

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human MYD88. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.18 mg/mL

Amount

118 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547087

Product Specific Information

Recommended positive controls: MyD88-transfected 293T.

Predicted reactivity: Mouse (82%), Rat (81%), Pig (86%), Sheep (83%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (84%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein 88; myleoid differentiation primary response protein; TLR adaptor MYD88; unnamed protein product

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Gene Aliases: IMD68; MYD88D; WM1

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UniProt ID: (Human) Q99836, (Mouse) P22366

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Entrez Gene ID: (Human) 4615, (Mouse) 17874

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Function(s)
receptor binding Toll binding death receptor binding cytokine receptor binding interleukin-1 receptor binding protein binding Toll-like receptor binding signaling adaptor activity identical protein binding binding, bridging TIR domain binding ATP-dependent histone chaperone activity
Process(es)
toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway chromatin organization chromatin remodeling phagocytosis apoptotic process signal transduction cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade Toll signaling pathway gene expression positive regulation of gene expression response to amine cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production positive regulation of interleukin-1 beta production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway toll-like receptor 8 signaling pathway toll-like receptor 9 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway interleukin-33-mediated signaling pathway defense response to bacterium defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid regulation of MAP kinase activity skin development NLRP3 inflammasome complex assembly innate immune response response to ethanol positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of inflammatory response defense response to Gram-positive bacterium defense response to virus type I interferon signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly response to molecule of fungal origin neutrophil activation involved in immune response inflammatory response immune response transmembrane receptor protein serine/threonine kinase signaling pathway response to virus induced systemic resistance regulation of gene expression microglia differentiation immunoglobulin mediated immune response neurogenesis response to peptidoglycan response to lipopolysaccharide regulation of interleukin-6 production regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of tumor necrosis factor production regulation of toll-like receptor 4 signaling pathway NIK/NF-kappaB signaling regulation of cell proliferation positive regulation of JNK cascade positive regulation of lymphocyte proliferation neutrophil mediated killing of bacterium establishment of endothelial intestinal barrier regulation of neutrophil migration regulation of chemokine (C-X-C motif) ligand 1 production regulation of chemokine (C-X-C motif) ligand 2 production
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