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Invitrogen

GATA2 Polyclonal Antibody

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View all (20) GATA2 antibodies

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Product Details

PA5-29736

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human GATA2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Amount

38 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547210

Product Specific Information

Recommended positive controls: A549, HeLa, HepG2, HCT116, H1299.

Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (87%), Pig (99%), Chicken (86%), Bovine (92%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ45948; GATA-bindning protein 2; MGC2306; unnamed protein product

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Gene Aliases: DCML; Gata-2; IMD21; MONOMAC; NFE1B

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UniProt ID: (Human) P23769, (Rat) Q924Y4, (Mouse) O09100

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Entrez Gene ID: (Human) 2624, (Rat) 25159, (Mouse) 14461

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding C2H2 zinc finger domain binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter urogenital system development cell fate determination neuron migration embryonic placenta development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cytosolic calcium ion concentration positive regulation of gene expression negative regulation of gene expression regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development pituitary gland development cell differentiation neuron differentiation response to lipid somatic stem cell population maintenance eosinophil fate commitment inner ear morphogenesis positive regulation of mast cell degranulation positive regulation of blood vessel endothelial cell migration cell fate commitment fat cell differentiation negative regulation of fat cell differentiation negative regulation of myeloid cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter cell maturation animal organ development neuron fate commitment homeostasis of number of cells within a tissue positive regulation of phagocytosis regulation of developmental process positive regulation of phagocytosis, engulfment definitive hemopoiesis semicircular canal development vascular wound healing positive regulation of cell migration involved in sprouting angiogenesis cochlea development GABAergic neuron differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation negative regulation of endothelial cell apoptotic process regulation of forebrain neuron differentiation anatomical structure morphogenesis positive regulation of transcription, DNA-templated system development regulation of multicellular organismal process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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