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Invitrogen

Neuropilin 1 Polyclonal Antibody

View all (55) Neuropilin 1 (CD304) antibodies

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Product Details

PA5-29860

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Extracellular domain of human Neuropilin 1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Amount

60 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547334

Product Specific Information

Recommended positive controls: K562.

Predicted reactivity: Mouse (93%), Rat (93%), Chicken (86%), Rhesus Monkey (97%), Bovine (93%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternatively spliced; lacks exon 16; Neuropilin; Neuropilin1; NRP 1; receptor for VEGF165 and semaphorins class 3; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; unnamed protein product; vascular endothelial cell growth factor 165 receptor; VEGF 165 receptor

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Gene Aliases: BDCA4; CD304; NP1; NRP; VEGF165R

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UniProt ID: (Human) O14786

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Entrez Gene ID: (Human) 8829

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Function(s)
vascular endothelial growth factor-activated receptor activity GTPase activator activity protein binding coreceptor activity semaphorin receptor activity growth factor binding protein kinase binding cytokine binding vascular endothelial growth factor binding
Process(es)
angiogenesis patterning of blood vessels vasculogenesis neural crest cell migration neuron migration positive regulation of endothelial cell proliferation sprouting angiogenesis cell migration involved in sprouting angiogenesis outflow tract septum morphogenesis substrate-dependent cell migration, cell extension signal transduction integrin-mediated signaling pathway cell-cell signaling axon guidance motor neuron axon guidance response to wounding organ morphogenesis positive regulation of endothelial cell migration positive regulation of smooth muscle cell migration facial nerve structural organization trigeminal nerve structural organization vestibulocochlear nerve structural organization branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus regulation of vascular endothelial growth factor receptor signaling pathway retinal ganglion cell axon guidance regulation of Cdc42 protein signal transduction cellular response to hepatocyte growth factor stimulus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus ventral trunk neural crest cell migration vascular endothelial growth factor signaling pathway neuropilin signaling pathway VEGF-activated neuropilin signaling pathway positive regulation of phosphorylation negative regulation of neuron apoptotic process endothelial cell migration positive regulation of angiogenesis viral entry into host cell platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway neuron development positive regulation of axon extension involved in axon guidance artery morphogenesis axon extension involved in axon guidance positive chemotaxis positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of focal adhesion assembly axonogenesis involved in innervation regulation of vesicle-mediated transport angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis retina vasculature morphogenesis in camera-type eye renal artery morphogenesis sympathetic ganglion development trigeminal ganglion development positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway commissural neuron axon guidance positive regulation of cell migration involved in sprouting angiogenesis endothelial tip cell fate specification sensory neuron axon guidance motor neuron migration sympathetic neuron projection extension sympathetic neuron projection guidance postsynapse organization regulation of plasma membrane bounded cell projection organization basal dendrite development basal dendrite arborization positive regulation of substrate adhesion-dependent cell spreading neural crest cell migration involved in autonomic nervous system development protein localization to early endosome facioacoustic ganglion development dorsal root ganglion morphogenesis otic placode development negative regulation of extrinsic apoptotic signaling pathway
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