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Invitrogen
TRPA1 Polyclonal Antibody
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Product Details
PA5-34282
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 19 amino acid peptide from internal region of human TRPA1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Marmoset, Bovine (89%) Monkey, Elephant, Dog, Rabbit, Pig (84%).
Target Information
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; nompC; p120; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; TRPA-1; Wasabi receptor
Gene Aliases: ANKTM1; FEPS; FEPS1; p120; TRPA1
UniProt ID: (Human) O75762
Entrez Gene ID: (Human) 8989
system process
ion transport
calcium ion transport
cellular calcium ion homeostasis
cell surface receptor signaling pathway
response to cold
response to xenobiotic stimulus
urinary bladder smooth muscle contraction
sensory perception of pain
calcium-mediated signaling
cellular response to stress
ion transmembrane transport
cellular response to heat
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to hydrogen peroxide
response to pain
thermoception
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception
protein homotetramerization
transmembrane transport
cellular response to hydrogen peroxide
cellular response to cold
calcium ion transmembrane transport
cellular response to food
cellular response to carbon dioxide
cellular response to caffeine
cellular response to toxic substance
calcium ion transmembrane import into cytosol
regulation of neuronal action potential
cellular response to oxygen-containing compound
regulation of blood circulation
positive regulation of monoatomic anion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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