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Invitrogen
KANK2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-34539
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the carboxy terminus of human KANK2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse brain tissue lysate.
PA5-34539 can be used with blocking peptide PEP-1582.
Target Information
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANKRD25; ankyrin repeat domain 25; ankyrin repeat domain-containing protein 25; kidney ankyrin repeat-containing protein 2; matrix-remodeling-associated protein 3; SIP; SRC-interacting protein; SRC1-interacting protein; steroid receptor coactivator interacting protein; unnamed protein product
Gene Aliases: ANKRD25; MXRA3; NPHS16; PPKWH; RGD1563532; SIP
UniProt ID: (Human) Q63ZY3, (Mouse) Q8BX02, (Rat) D3ZD05
Entrez Gene ID: (Human) 25959, (Mouse) 235041, (Rat) 100361376
negative regulation of transcription from RNA polymerase II promoter
establishment or maintenance of cell polarity
negative regulation of cell proliferation
negative regulation of actin filament polymerization
negative regulation of intracellular estrogen receptor signaling pathway
regulation of Rho protein signal transduction
negative regulation of programmed cell death
negative regulation of vitamin D receptor signaling pathway
kidney epithelium development
glomerular visceral epithelial cell migration
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of stress fiber assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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