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Invitrogen
Plasminogen Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-34677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Plasminogen. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.18 mg/mL
Amount
18 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Jurkat, Raji, K562, BCL-1, PC-12, Rat2, human plasma, mouse plasma, rat plasma.
Predicted reactivity: Rat (80%), Dog (81%), Pig (80%), Rhesus Monkey (93%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiostatin; DKFZp779M0222; liver regeneration-related protein LRRG051; plasmin; plasmin heavy chain A; plasmin light chain B; plasminogen; RP1-81D8.1; unnamed protein product
Gene Aliases: Ab1-346; HAE4; Pg
UniProt ID: (Human) P00747, (Rat) Q01177, (Mouse) P20918
Entrez Gene ID: (Human) 5340, (Rat) 85253, (Mouse) 18815
proteolysis
blood coagulation
negative regulation of cell-substrate adhesion
protein processing
extracellular matrix disassembly
protein catabolic process
collagen catabolic process
tissue regeneration
fibrinolysis
positive regulation of blood vessel endothelial cell migration
myoblast differentiation
muscle cell cellular homeostasis
negative regulation of fibrinolysis
positive regulation of fibrinolysis
trophoblast giant cell differentiation
labyrinthine layer blood vessel development
mononuclear cell migration
trans-synaptic signaling by BDNF, modulating synaptic transmission
interaction with symbiont
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of angiogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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