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Invitrogen

Phospho-FMRP (Ser499) Polyclonal Antibody

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View all (23) FMRP antibodies

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Phospho-FMRP (Ser499) Polyclonal Antibody

Product Details

PA5-35389

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

1:250-1:1,000
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 of rat FMR1 conjugated to KLH
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Amount

40 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.1mg/mL BSA, 0.15M NaCl, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2552699

Product Specific Information

This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, sheep, Xenopus and zebrafish based on 100% sequence homology.

This antibody contains enough material to conduct 10 mini-Western blots.

Target Information

FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FMRP; FMRP translational regulator 1; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; mFmr1p; MGC87458; Protein FMR-1; ragile X mental retardation protein; synaptic functional regulator FMR1; unnamed protein product

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Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1

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UniProt ID: (Human) Q06787, (Rat) Q80WE1, (Mouse) P35922

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Entrez Gene ID: (Chicken) 422395, (Human) 2332, (Rat) 24948, (Mouse) 14265

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Function(s)
G-quadruplex RNA binding nucleic acid binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding microtubule binding poly(U) RNA binding translation repressor activity translation initiation factor binding RNA strand annealing activity poly(G) binding siRNA binding miRNA binding signaling adaptor activity RNA stem-loop binding identical protein binding protein homodimerization activity ribosome binding ion channel binding macromolecular complex binding translation regulator activity protein heterodimerization activity mRNA 5'-UTR binding dynein complex binding histone H3 reader activity molecular condensate scaffold activity N6-methyladenosine-containing RNA binding sequence-specific mRNA binding poly(A) RNA binding translation factor
Process(es)
deadenylation-dependent decapping of nuclear-transcribed mRNA regulation of alternative mRNA splicing, via spliceosome positive regulation of receptor internalization DNA repair chromatin organization mRNA processing mRNA export from nucleus regulation of translation cellular response to DNA damage stimulus glutamate receptor signaling pathway nervous system development RNA splicing regulation of cell communication negative regulation of translation gene silencing by RNA stress granule assembly regulation of mRNA stability modulation by host of viral RNA genome replication positive regulation of translation negative regulation of translational initiation regulation of neurotransmitter secretion positive regulation of long-term neuronal synaptic plasticity animal organ development mRNA transport positive regulation of cellular component organization regulation of filopodium assembly positive regulation of filopodium assembly negative regulation of gene silencing by miRNA regulation of dendritic spine development positive regulation of dendritic spine development regulation of biological quality cellular response to virus regulation of neuronal action potential regulation of translation at presynapse, modulating synaptic transmission membraneless organelle assembly negative regulation of long term synaptic depression positive regulation of intracellular transport of viral material negative regulation of voltage-gated calcium channel activity positive regulation of proteasomal protein catabolic process negative regulation of synaptic vesicle exocytosis positive regulation of gene silencing by miRNA negative regulation of cytoplasmic translation central nervous system development transport dendritic spine development
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