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Invitrogen
Aurora B/C Polyclonal Antibody
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FIGURE: 1 / 1
Aurora B/C Antibody (PA5-36126) in WB
Western blot analysis of Aurora B/C in Lane 1: HEK293T whole cell lysate (20 µg), Lane 2: HepG2 whole cell lysate (20 µg), Lane 3: PC3 whole cell lysate (40 µg), Lane 4: A549 whole cell lysate (40 µg), Lane 5: PC12 whole cell lysate (40 µg), Lane 6: AML-12 whole cell lysate (40 µg). Samples were incubated with Aurora B/C polyclonal antibody (Product # PA5-36126) at a dilution of 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36126
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 163-213 of human AURKB
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 35 and 39 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIM-1; ARK-2; ARK-3; aurora 1; aurora 3; aurora B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and IPL1-like midbody-associated protein 1; aurora- and Ipl1-like midbody-associated protein 1 homolog; aurora-1; aurora-B; aurora-related kinase 2; aurora-related kinase 3; aurora/Ipl1-like kinase; aurora/IPL1-related kinase 2; aurora/IPL1-related kinase 3; aurora/Ipl1/Eg2 protein 1; aurora/IPL1/EG2 protein 2; epididymis secretory protein Li 90; protein kinase; chromosomal passenger protein; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase 13; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; serine/threonine-protein kinase aurora-C; unnamed protein product; zinc finger protein 264-like; zinc finger protein 805-like
Gene Aliases: AIE1; AIE2; AIK2; AIK3; AIM-1; AIM1; AIRK2; ARK-2; ARK-3; ARK2; ARK3; AurB; AurC; aurkb-sv1; aurkb-sv2; aurora-C; HEL-S-90; IAK3; IPL1; PPP1R48; SPGF5; STK-1; STK12; STK13; STK5
UniProt ID: (Human) Q96GD4, (Human) Q9UQB9, (Rat) O55099, (Mouse) O70126, (Mouse) O88445
Entrez Gene ID: (Human) 9212, (Human) 6795, (Rat) 114592, (Mouse) 20877, (Rat) 292554, (Mouse) 20871
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
chromatin remodeling
spindle organization
mitotic spindle organization
positive regulation of microtubule depolymerization
positive regulation of telomere maintenance
regulation of cytokinesis
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
post-translational protein modification
cell cycle G2/M phase transition
mitotic cytokinesis checkpoint
negative regulation of innate immune response
mitotic spindle midzone assembly
midbody abscission
positive regulation of mitotic sister chromatid segregation
negative regulation of protein localization to chromatin
repair of mitotic kinetochore microtubule attachment defect
negative regulation of cGAS/STING signaling pathway
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
mitotic sister chromatid biorientation
regulation of transcription, DNA-templated
protein phosphorylation
protein autophosphorylation
mitotic cell cycle
mitotic cytokinesis
regulation of microtubule-based process
regulation of chromosome segregation
positive regulation of cell cycle process
positive regulation of mitotic cell cycle spindle assembly checkpoint
mitotic spindle assembly
regulation of signal transduction by p53 class mediator
positive regulation of mitotic sister chromatid separation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitotic cytokinesis
attachment of spindle microtubules to kinetochore
regulation of cell cycle process
spindle assembly
positive regulation of protein phosphorylation
attachment of mitotic spindle microtubules to kinetochore
cGAS/STING signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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