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Invitrogen
ADORA3 Polyclonal Antibody
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FIGURE: 1 / 2
ADORA3 Antibody (PA5-36350) in IHC (P)
Immunohistochemistry analysis of ADORA3 in paraffin-embedded human tonsil carcinoma tissue (cytoplasmic and perinuclear staining) and negative control (right, with PBS only). Samples were incubated with ADORA3 polyclonal antibody (Product # PA5-36350) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36350
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat,
Rhesus monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids C-terminus of human ADORA3
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 38 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthesis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNF alpha and blocks the endotoxin CD14 receptor signal transduction pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AD026; Adenosine A3-R; BA552M11.5; G-protein coupled receptor 2; RP11-552M11.7; unnamed protein product
Gene Aliases: A3AR; A3R; AA3R; ARA3; Gpcr2
UniProt ID: (Human) P0DMS8
Entrez Gene ID: (Human) 140, (Mouse) 11542
adenosine receptor signaling pathway
histamine secretion by mast cell
positive regulation of leukocyte migration
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of heart contraction
negative regulation of cell proliferation
regulation of cell communication
regulation of norepinephrine secretion
regulation of signaling
negative regulation of cell migration
positive regulation of mast cell degranulation
positive regulation of inflammatory response
positive regulation of calcium-mediated signaling
positive regulation of protein kinase B signaling
positive regulation of mucus secretion
presynaptic modulation of chemical synaptic transmission
inflammatory response
signal transduction
activation of adenylate cyclase activity
response to wounding
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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