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          • Primary Antibodies ›
          • ABL1/ABL2 Antibodies

          Invitrogen

          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody

          View all (6) ABL1/ABL2 antibodies

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          Cite Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (2)
          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Antibody (PA5-36821) in IHC (P)

          Immunohistochemistry analysis of Phospho-ABL1/ABL2 (Tyr393, Tyr439) in paraffin-embedded human breast carcinoma tissue (cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with Phospho-ABL1/ABL2 (Tyr393, Tyr439) polyclonal antibody (Product # PA5-36821) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-ABL1/ABL2 (Tyr393, Tyr439) Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Product Details

          PA5-36821

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic phosphopeptide derived from human ABL1/2 around the phosphorylation site of Tyrosine 393/439

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2553756

          Product Specific Information

          This antibody detects endogenous protein at a molecular weight of 123 kDa.

          Purity is >95% by SDS-PAGE.

          Target Information

          The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Bioinformatics

          Protein Aliases: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral (v-abl) oncogene homolog 2; abelson murine leukemia viral oncogene homolog 1; abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 1; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; ABL kinase domain; abl protein; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; Abl1-related gene product; arg tyrosine kinase; BCR-ABL1 p190; BCR/ABL e8a2 fusion; BCR/ABL variant p190 fusion protein; BCR/ABL variant-p210 fusion protein; BCR/ABL1 e1a2 fusion protein; BCR/ABL1 fusion; BCR/ABL1 fusion protein e3a1; bcr/c-abl oncogene protein; BCR::ABL1 fusion protein; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; c-abl-protein type I; c-abl-protein type II; c-abl-protein type III; c-abl-protein type IV; chimeric BCR::ABL1 protein; H1681-BCR/ABL variant p210 fusion protein; non-receptor tyrosine kinase; nonreceptor tyrosine kinase; p150; p190; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine kinase ARG; tyrosine kinase protein; tyrosine-protein kinase ABL1-like; tyrosine-protein kinase ARG; unnamed protein product; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene); v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

          View more View less

          Gene Aliases: ABL; ABLL; ARG; BCR-ABL; bcr/abl; c-ABL; c-ABL1; CHDSKM; E430008G22Rik; JTK7; p150; v-abl

          View more View less

          UniProt ID: (Human) P00519, (Human) P42684, (Mouse) P00520

          View more View less

          Entrez Gene ID: (Human) 25, (Human) 27, (Rat) 311860, (Mouse) 11350, (Mouse) 11352, (Rat) 304883

          View more View less

          Function(s)
          magnesium ion binding four-way junction DNA binding bubble DNA binding phosphotyrosine binding DNA binding transcription coactivator activity actin monomer binding nicotinate-nucleotide adenylyltransferase activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding protein binding ATP binding enzyme activator activity kinase activity enzyme binding protein kinase binding protein domain specific binding syntaxin binding manganese ion binding neuropilin binding SH2 domain binding protein serine/threonine kinase activator activity ephrin receptor binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding delta-catenin binding supercoiled DNA binding sequence-specific double-stranded DNA binding nucleotide binding actin binding
          Process(es)
          signal transduction epidermal growth factor receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration regulation of autophagy positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of endocytosis regulation of cell adhesion regulation of actin cytoskeleton organization cellular response to oxidative stress negative regulation of Rho protein signal transduction exploration behavior protein modification process cellular response to retinoic acid positive regulation of establishment of T cell polarity regulation of cell motility positive regulation of T cell migration mitotic cell cycle immune effector process immune response-activating cell surface receptor signaling pathway mismatch repair regulation of transcription, DNA-templated phagocytosis cellular response to DNA damage stimulus response to oxidative stress integrin-mediated signaling pathway learning or memory associative learning intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus regulation of gene expression positive regulation of endothelial cell migration actin cytoskeleton organization actin filament polymerization regulation of axon extension phospholipase C-inhibiting G-protein coupled receptor signaling pathway regulation of microtubule polymerization regulation of Cdc42 protein signal transduction response to endoplasmic reticulum stress intracellular signal transduction platelet-derived growth factor receptor-beta signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis neuropilin signaling pathway signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of neuron apoptotic process endothelial cell migration regulation of T cell differentiation regulation of cell differentiation positive regulation of cell adhesion positive regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter platelet-derived growth factor receptor signaling pathway ephrin receptor signaling pathway positive regulation of fibroblast proliferation negative regulation of ubiquitin-protein transferase activity myoblast proliferation positive regulation of stress fiber assembly regulation of cell cycle mitochondrial depolarization positive regulation of focal adhesion assembly cardiac muscle cell proliferation cellular response to hydrogen peroxide DNA conformation change cellular response to transforming growth factor beta stimulus response to epinephrine positive regulation of cell migration involved in sprouting angiogenesis vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynaptic specialization assembly positive regulation of phospholipase C/protein kinase C signal transduction positive regulation of dendrite development positive regulation of substrate adhesion-dependent cell spreading negative regulation of long-term synaptic potentiation cellular response to oxygen-containing compound regulation of hematopoietic stem cell differentiation positive regulation of intracellular signal transduction positive regulation of extracellular matrix organization glomerular visceral epithelial cell apoptotic process cellular response to dopamine protein localization to cytoplasmic microtubule plus-end regulation of modification of synaptic structure positive regulation of blood vessel branching negative regulation of double-strand break repair via homologous recombination neural tube closure B-1 B cell homeostasis B cell proliferation involved in immune response transitional one stage B cell differentiation protein phosphorylation post-embryonic development cerebellum morphogenesis negative regulation of cell-cell adhesion microspike assembly neuron differentiation negative regulation of BMP signaling pathway positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading B cell proliferation regulation of cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle alpha-beta T cell differentiation protein autophosphorylation spleen development thymus development activated T cell proliferation T cell receptor signaling pathway B cell receptor signaling pathway neuromuscular process controlling balance regulation of transport positive regulation of release of sequestered calcium ion into cytosol Bergmann glial cell differentiation neuroepithelial cell differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide circulatory system development plasma membrane bounded cell projection assembly negative regulation of intracellular signal transduction regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process regulation of cellular senescence negative regulation of cellular senescence aggressive behavior substrate-dependent cell migration, cell extension actin filament organization learning adult walking behavior protein localization visual learning neuron remodeling auditory behavior multicellular organism growth dendrite morphogenesis actin filament bundle assembly synapse maturation dendritic spine maintenance biological_process
          It has to be done as per old AB suggested Products section.

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