Search

  • Contáctenos
  • Orden Rápida

Invitrogen

SLC22A2 Polyclonal Antibody

2 Published Figures
2 References
View all (12) SLC22A2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-37290

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to residues in human SLC22A2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553997

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 100 kDa.

Purity is >95% by SDS-PAGE.

Target Information

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2-Oct; hOCT2; mOCT2; Organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; Solute carrier family 22 member 2; solute carrier family 22, member 2; unnamed protein product

View more View less

Gene Aliases: OCT2; OCT2r; Orct2; rOCT2; SLC22A2

View more View less

UniProt ID: (Human) O15244, (Rat) Q9R0W2, (Mouse) O70577

View more View less

Entrez Gene ID: (Human) 6582, (Rat) 29503, (Mouse) 20518

View more View less

Function(s)
amine transmembrane transporter activity acetylcholine transmembrane transporter activity neurotransmitter transporter activity monoamine transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity prostaglandin transmembrane transporter activity L-amino acid transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity choline transmembrane transporter activity thiamine transmembrane transporter activity putrescine transmembrane transporter activity efflux transmembrane transporter activity spermidine transmembrane transporter activity quaternary ammonium group transmembrane transporter activity toxin transporter activity transmembrane transporter activity xenobiotic transporter activity L-arginine transmembrane transporter activity steroid binding ion transmembrane transporter activity transporter activity secondary carrier transporter
Process(es)
ion transport cation transport neurotransmitter transport serotonin transport body fluid secretion organic cation transport quaternary ammonium group transport prostaglandin transport amine transport putrescine transport spermidine transport acetylcholine transport choline transport dopamine transport norepinephrine transport xenobiotic transport epinephrine transport histamine transport serotonin uptake histamine uptake norepinephrine uptake transmembrane transport thiamine transmembrane transport purine-containing compound transmembrane transport amino acid import across plasma membrane dopamine uptake L-arginine import across plasma membrane export across plasma membrane transport across blood-brain barrier L-alpha-amino acid transmembrane transport spermidine transmembrane transport arginine transmembrane transport cellular detoxification drug transport across blood-brain barrier ion transmembrane transport cation transmembrane transport transport ammonium transmembrane transport
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support