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Invitrogen
Phospho-SNAIL (Ser246) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37739
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for Western blot is HT29 cells; suggested positive control for ICC/IF is HUVEC cells.
Target Information
Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein sna; protein snail homolog 1; similar to Mus musculus zinc finger protein Sna and to Drosophila melanogaster snail protein; sna; Sna protein; snai; Snai1; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail family zinc finger 1; snail homolog 1; unnamed protein product; zinc-finger protein
Gene Aliases: dJ710H13.1; SLUGH2; SNA; Sna1; SNAH; SNAIL; SNAIL1
UniProt ID: (Human) O95863, (Mouse) Q02085
Entrez Gene ID: (Human) 6615, (Mouse) 20613
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
kinase binding
sequence-specific DNA binding
E-box binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
mesoderm formation
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
mesoderm development
positive regulation of epithelial to mesenchymal transition
negative regulation of vitamin D biosynthetic process
cell migration
positive regulation of cell migration
hair follicle morphogenesis
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
palate development
canonical Wnt signaling pathway
cartilage morphogenesis
trophoblast giant cell differentiation
negative regulation of cell differentiation involved in embryonic placenta development
left/right pattern formation
heterochromatin organization
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of bicellular tight junction assembly
aortic valve morphogenesis
mesenchymal cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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