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Invitrogen

Phospho-JNK1/JNK2/JNK3 (Tyr185) Polyclonal Antibody

View all (25) JNK1/JNK2/JNK3 antibodies

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Phospho-JNK1/JNK2/JNK3 (Tyr185) Polyclonal Antibody

Product Details

PA5-40275

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

1:100-1:300
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Y185.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2608745

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 2; c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK 46; JNK 55; JNK-46; JNK-55; JNK/SAPK alpha; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; Jun kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase 9; MAP kinase p49 3F12; MAPK 10; MAPK 8; MAPK 9; MAPK8; MAPK9; MGC50974; Mi; mitogen activated protein kinase 10; mitogen activated protein kinase 8; mitogen activated protein kinase 9; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; Mitogen-activated protein kinase 9; MK10; p54 gamma; p54-alpha; p54-beta; Phospho-JNK; protein kinase mitogen-activated 8; protein kinase, mitogen-activated 9; SAPK gamma; SAPK-alpha; SAPK-beta; SAPK/Erk/kinase 2; SAPK1a; SAPK1b; SAPK1c; stress activated protein kinase alpha II; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1a; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK2; Stress-activated protein kinase JNK3; unnamed protein product

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Gene Aliases: AI849689; AI851083; C230008H04Rik; JNK; JNK-46; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; MAPK9; p493F12; p54a; p54aSAPK; p54bSAPK; PRKM10; PRKM8; PRKM9; SAPb; SAPK; SAPK(beta); SAPK1; SAPK1A; SAPK1B; SAPK1C; SAPKC; Serk2

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UniProt ID: (Human) P53779, (Human) P45983, (Human) P45984, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86, (Rat) P49186, (Mouse) Q9WTU6

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Entrez Gene ID: (Human) 5602, (Human) 5599, (Human) 5601, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419, (Rat) 50658, (Mouse) 26420

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding kinase activity transferase activity protein serine kinase activity enzyme binding protein phosphatase binding histone deacetylase regulator activity histone deacetylase binding protein serine/threonine kinase binding protein serine/threonine/tyrosine kinase activity transferase activity, transferring phosphorus-containing groups transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade protein phosphorylation signal transduction JNK cascade response to light stimulus Fc-epsilon receptor signaling pathway regulation of circadian rhythm rhythmic process cellular senescence double-strand break repair response to oxidative stress JUN phosphorylation response to UV response to mechanical stimulus positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of cyclase activity positive regulation of cell killing negative regulation of protein binding regulation of protein localization cellular response to amino acid starvation cellular response to oxidative stress cellular response to reactive oxygen species positive regulation of apoptotic process negative regulation of apoptotic process regulation of mRNA stability NLRP3 inflammasome complex assembly positive regulation of protein metabolic process stress-activated MAPK cascade mRNA destabilization protein poly-ADP-ribosylation cellular response to lipopolysaccharide cellular response to mechanical stimulus energy homeostasis positive regulation of NLRP3 inflammasome complex assembly positive regulation of establishment of protein localization to mitochondrion protein localization to site of double-strand break positive regulation of macrophage derived foam cell differentiation positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process response to cadmium ion modulation of synaptic transmission protein localization to tricellular tight junction positive regulation of podosome assembly inflammatory response to wounding apoptotic signaling pathway positive regulation of cytokine production involved in inflammatory response positive regulation of apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter phosphorylation locomotor rhythm ossification regulation of transcription, DNA-templated inflammatory response response to osmotic stress response to heat regulation of gene expression positive regulation of cell migration regulation of histone deacetylation positive regulation of microtubule polymerization neuron projection development response to hydrogen peroxide positive regulation of DNA replication determination of dorsal identity cellular response to hydrogen peroxide cellular response to nitric oxide positive regulation of deacetylase activity type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein targeting to mitochondrion activation of cysteine-type endopeptidase activity involved in apoptotic process central nervous system development response to toxic substance response to organic substance positive regulation of cell morphogenesis involved in differentiation response to amine positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV response to drug positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade positive regulation of nitric-oxide synthase biosynthetic process cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus
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