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Invitrogen
CDT1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-42861
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human CDT1 (aa 400-449).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: PATPPATPPA ASPSALKGVS QDLLERIRAK EAQKQLAQMT RCPEQEQRLQ
Sequence homology: Cow: 93%; Dog: 77%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Yeast: 85%
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDT1; double parked homolog; Double parked, Drosophila, homolog of; retroviral insertion site 2 protein; retroviral integration site 1; retroviral integration site 2; RIS2; unnamed protein product
Gene Aliases: 2610318F11Rik; DUP; RIS2
UniProt ID: (Human) Q9H211, (Mouse) Q8R4E9
Entrez Gene ID: (Human) 81620, (Rat) 292071, (Mouse) 67177
DNA replication checkpoint
mitotic cell cycle
regulation of DNA-dependent DNA replication initiation
regulation of nuclear cell cycle DNA replication
positive regulation of DNA replication
negative regulation of cell cycle
attachment of mitotic spindle microtubules to kinetochore
DNA replication preinitiation complex assembly
response to sorbitol
regulation of DNA-dependent DNA replication
mitotic DNA replication initiation
mitotic pre-replicative complex assembly
negative regulation of DNA-dependent DNA replication
positive regulation of DNA-dependent DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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