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Invitrogen
GPIHBP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-45576
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human GPIHBP1 (aa 125-174).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: QVTMTCCQSS LCNVPPWQSS RVQDPTGKGA GGPRGSSETV GAALLLNLLA
Sequence homology: Human: 100%
Target Information
GPI-anchored HDL-binding protein 1 (Gpihbp1) is a novel protein that may be involved in the regulation of the delivery of fats to cells for energy and storage. Digested fats travel to the small intestine, where they are packaged into chylomicrons (particles filled with triglycerides). Chylomicrons then travel through the bloodstream and deliver triglycerides to tissues that are hungry for fuel or to adipose tissue for energy storage. Triglycerides are broken down or hydrolyzed by the enzyme lipoprotein lipase (LpL). The triglyceride breakdown products are then taken up and used by cells. Gpihbp1 is the molecule in capillaries that facilitates the capture of chylomicrons and facilitates the interaction with LpL. It has been shown that fats in the bloodstream are not readily metabolized in the absence of GPIHBP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein 1; GPI-anchored HDL-binding protein 1; HDLBP; HDLBP1
Gene Aliases: GPI-HBP1; HYPL1D
UniProt ID: (Human) Q8IV16
Entrez Gene ID: (Human) 338328
intracellular protein transport
protein import
triglyceride catabolic process
positive regulation of lipid transport
protein localization to cell surface
cholesterol homeostasis
transcytosis
positive regulation of fatty acid biosynthetic process
protein stabilization
triglyceride homeostasis
response to heparin
positive regulation of chylomicron remodeling
positive regulation of chylomicron remnant clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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