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Invitrogen

MCP-1 Polyclonal Antibody

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MCP-1 Polyclonal Antibody

Product Details

PA5-46954

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
View 1 publication 1 publication

ELISA (ELISA)

0.1-0.4 µg/mL (Detection), 0.2-0.8 µg/mL (Capture)
-

Neutralization (Neu)

0.5-2.5 µg/mL
-
Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived recombinant mouse CCL2/JE/MCP-1 Gln24-Arg96
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL once reconstituted

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609536

Product Specific Information

In sandwich ELISAs, less than 0.01% cross-reactivity with recombinant human (rh) MCP-1, rhMCP-2, rhMCP-3, recombinant mouse (rm) MARC, rhMCP-4, rmMCP-5, rmMDC, rmMIP-1 alpha, rmMIP-1 beta, rmMIP-1 gamma, rmMIP-2, rmMIP-3 beta, rmRANTES, rmTARC, and rmTeck is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ccl2; chemokine (C-C motif) ligand 2; H-MCP-1; JE; MGC9434; monocyte chemoattractant protein 1; monocyte chemotactic protein 1; platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small-inducible cytokine A2; unnamed protein product

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Gene Aliases: HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje; SMC-CF

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UniProt ID: (Mouse) P10148

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Entrez Gene ID: (Mouse) 20296

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Function(s)
G-protein coupled receptor binding cytokine activity protein binding chemokine activity heparin binding CCR2 chemokine receptor binding chemoattractant activity CCR chemokine receptor binding
Process(es)
angiogenesis response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response chronic inflammatory response monocyte chemotaxis positive regulation of leukocyte migration positive regulation of cellular extravasation cellular calcium ion homeostasis inflammatory response immune response cytoskeleton organization transforming growth factor beta receptor signaling pathway glial cell migration regulation of cell shape response to xenobiotic stimulus response to wounding response to mechanical stimulus response to bacterium response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain positive regulation of cell-cell adhesion positive regulation of cell migration neutrophil chemotaxis organ regeneration response to lipopolysaccharide response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 negative regulation of glial cell apoptotic process response to tumor necrosis factor helper T cell extravasation monocyte homeostasis response to isolation stress cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus chemokine (C-C motif) ligand 2 signaling pathway response to amino acid negative regulation of neuron apoptotic process astrocyte cell migration response to ethanol positive regulation of cell adhesion vascular endothelial growth factor receptor signaling pathway eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of synaptic transmission positive regulation of T cell activation positive chemotaxis response to glucocorticoid positive regulation of synaptic transmission, glutamatergic mammary gland involution maternal process involved in female pregnancy maternal process involved in parturition antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to ATP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to fatty acid cellular response to lipoprotein particle stimulus cellular response to high density lipoprotein particle stimulus cellular response to xenobiotic stimulus cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of calcium ion import positive regulation of wound healing positive regulation of protein targeting to membrane energy homeostasis positive regulation of glutamate receptor signaling pathway response to cyclosporin A negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
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