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Invitrogen

CD105 Polyclonal Antibody

View all (112) CD105 (Endoglin) antibodies

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CD105 Polyclonal Antibody

Product Details

PA5-46971

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

5-15 µg/mL
-

Immunocytochemistry (ICC/IF)

5-15 µg/mL
-

Flow Cytometry (Flow)

2.5 µg per million cells
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Endoglin/CD105 Glu27-Gly581
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL once reconstituted

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607336

Product Specific Information

In direct ELISAs, less than 20% cross-reactivity with recombinant rat Endoglin is observed and less than 5% cross-reactivity with recombinant human Endoglin is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD 105; cell surface MJ7/18 antigen; co-receptor; ORW; TGF-beta receptor III homolog; transmembrane glycoprotein; unnamed protein product

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Gene Aliases: CD105; Endo; S-endoglin

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UniProt ID: (Mouse) Q63961

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Entrez Gene ID: (Mouse) 13805

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Function(s)
type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding coreceptor activity receptor activator activity type I transforming growth factor beta receptor binding BMP binding identical protein binding protein homodimerization activity transforming growth factor beta binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis patterning of blood vessels vasculogenesis response to hypoxia positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation heart looping sprouting angiogenesis positive regulation of systemic arterial blood pressure outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated transforming growth factor beta receptor signaling pathway heart development positive regulation of gene expression negative regulation of gene expression regulation of cardiac muscle cell apoptotic process cell migration regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis extracellular matrix disassembly negative regulation of cell migration positive regulation of BMP signaling pathway positive regulation of collagen biosynthetic process dorsal aorta morphogenesis wound healing positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis cell motility positive regulation of protein kinase B signaling atrial cardiac muscle tissue morphogenesis cell chemotaxis positive regulation of SMAD protein import into nucleus negative regulation of SMAD protein import into nucleus extracellular matrix constituent secretion detection of hypoxia endocardial cushion to mesenchymal transition vascular smooth muscle cell development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of vascular smooth muscle cell differentiation cardiac jelly development atrioventricular canal morphogenesis regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of cell proliferation involved in heart morphogenesis
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