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Invitrogen
ACVR2B Polyclonal Antibody
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FIGURE: 1 / 1
ACVR2B Antibody (PA5-47005) in IHC (P)
Immunohistochemical analysis of ACVR2B in immersion fixed paraffin-embedded sections of human placenta (cross-section of chorionic villi). Samples were incubated in ACVR2B polyclonal antibody (Product # PA5-47005) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Activin RIIB Ser19-Thr134
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Activin RIIB is observed, and less than 1% cross-reactivity with recombinant human (rh) Activin RIIA, rhActivin RIA, and rhActivin RIB is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin A receptor, type IIB; MGC116908; probable match to ACTIVIN RECEPTOR TYPE IIB PRECURSOR (ACTR-IIB)
Gene Aliases: ActR-IIB; ACTRIIB; HTX4
UniProt ID: (Human) Q13705
Entrez Gene ID: (Human) 93
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
activin receptor activity, type II
activin-activated receptor activity
kinase activator activity
growth factor binding
activin binding
negative regulation of transcription from RNA polymerase II promoter
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
cellular iron ion homeostasis
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
pattern specification process
anterior/posterior pattern specification
negative regulation of ossification
positive regulation of bone mineralization
BMP signaling pathway
developmental process
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
trophoblast cell migration
cellular response to growth factor stimulus
negative regulation of cold-induced thermogenesis
negative regulation of adipose tissue development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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