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Invitrogen

CD148 Polyclonal Antibody

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CD148 Polyclonal Antibody

Product Details

PA5-47225

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunoprecipitation (IP)

2.5 µg/500 µg cell lysate
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived recombinant human DEP-1/CD148 Arg997-Ala1337
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL once reconstituted

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607994

Product Specific Information

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD148 antigen; colon tumor susceptibility 1; density enhanced phosphatase-1; density-enhanced phosphatase 1; HPTP beta-like tyrosine phosphatase; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; receptor tyrosine phosphatase; susceptibility to colon cancer 1; susceptibility to colon cancer 1, mouse, homolog of; unnamed protein product

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Gene Aliases: BET; Byp; CD148; DEP-1; DEP1; HPTP eta; HPTPeta; Ptpb2; PTPbeta2; R-PTP-ETA; R-PTP-J; RPTPJ; Scc-1; SCC1; THC10

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UniProt ID: (Human) Q12913, (Mouse) Q64455

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Entrez Gene ID: (Human) 5795, (Mouse) 19271, (Rat) 29645

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Function(s)
protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding beta-catenin binding phosphatase activity protein kinase binding gamma-catenin binding cadherin binding mitogen-activated protein kinase binding delta-catenin binding identical protein binding
Process(es)
vasculogenesis positive regulation of cell-matrix adhesion immune system process signal transduction axon guidance heart development blood coagulation negative regulation of cell proliferation anatomical structure morphogenesis positive regulation of platelet activation negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of macrophage chemotaxis hemopoiesis regulation of cell adhesion B cell differentiation platelet formation negative regulation of cell growth negative regulation of cell migration positive regulation of tumor necrosis factor production peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway glucose homeostasis negative regulation of vascular permeability negative regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of cell adhesion negative regulation of insulin receptor signaling pathway platelet-derived growth factor receptor signaling pathway oligodendrocyte differentiation positive regulation of phagocytosis positive regulation of immune response positive regulation of calcium-mediated signaling negative regulation of T cell receptor signaling pathway positive chemotaxis positive regulation of cellular component organization positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of intracellular signal transduction peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity negative regulation of receptor activity cytokine-mediated signaling pathway T cell receptor signaling pathway contact inhibition
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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