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Invitrogen
CLEC12A Polyclonal Antibody
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Product Details
PA5-47423
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A isoform a Thr67-Ala265
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, approximately 15% cross-reactivity with recombinant mouse MICL is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CD371 is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin protein CLL-1; C-type lectin superfamily; C-type lectin-like molecule-1; DCAL-2; dendritic cell-associated lectin 2; killer cell C-type lectin-like receptor L1; MICL-alpha; type II transmembrane protein; MICL-beta; type II transmembrane protein; MICL-gamma; type II transmembrane protein; myeloid inhibitory C-type lectin-like receptor; unnamed protein product
Gene Aliases: CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL
UniProt ID: (Human) Q5QGZ9
Entrez Gene ID: (Human) 160364
signal transduction
positive regulation of type I interferon production
negative regulation of natural killer cell activation
negative regulation of inflammatory response
negative regulation of immune response
negative regulation of neutrophil activation
negative regulation of dendritic cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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