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Invitrogen
Neuropilin 2 Polyclonal Antibody
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FIGURE: 1 / 3
Neuropilin 2 Antibody (PA5-47762) in IHC (F)
Immunohistochemical analysis of Neuropilin 2 in perfusion fixed frozen sections of rat brain. Samples were incubated in Neuropilin 2 polyclonal antibody (Product # PA5-47762) using a dilution of 15 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm in neurons.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47762
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant rat Neuropilin-2 Gln23-Asp857 (Val809-Asp825 del)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, approximately 25% cross–reactivity with recombinant human Neuropilin-2 is observed, and less than 5% cross-reactivity with recombinant rat Neuropilin-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) and SEMA3F protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: type I transmembrane protein; unnamed protein product; vascular endothelial cell growth factor 165 receptor 2
Gene Aliases: 1110048P06Rik; Np-2; Np2; Npn-2; Npn2
UniProt ID: (Mouse) O35375, (Rat) O35276
Entrez Gene ID: (Mouse) 18187, (Rat) 81527
angiogenesis
neural crest cell migration
neuron migration
outflow tract septum morphogenesis
axon guidance
heart development
facial nerve structural organization
vestibulocochlear nerve structural organization
nerve development
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
ventral trunk neural crest cell migration
vascular endothelial growth factor signaling pathway
axon extension involved in axon guidance
negative chemotaxis
sympathetic ganglion development
trigeminal ganglion development
semaphorin-plexin signaling pathway
sensory neuron axon guidance
sympathetic neuron projection extension
sympathetic neuron projection guidance
regulation of postsynapse organization
neural crest cell migration involved in autonomic nervous system development
facioacoustic ganglion development
dorsal root ganglion morphogenesis
cellular response to leukemia inhibitory factor
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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