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Invitrogen
LOXL3 Polyclonal Antibody
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FIGURE: 1 / 3
LOXL3 Antibody (PA5-48462) in IHC (P)
Immunohistochemistry analysis of LOXL3 in formalin fixed and paraffin embedded human placenta tissue. Samples were incubated with LOXL3 polyclonal antibody (Product # PA5-48462) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-48462
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 715-744 amino acids from the C-terminal region of human LOXL3.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with mouse based on sequence homology.
Target Information
LOXL3 is a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amine oxidase; LOXL3; Lysyl oxidase homolog 3; Lysyl oxidase-like protein 3
Gene Aliases: LOXL; LOXL3; MYP28
UniProt ID: (Human) P58215
Entrez Gene ID: (Human) 84695
epithelial to mesenchymal transition
inflammatory response
JAK-STAT cascade
tissue development
peptidyl-lysine oxidation
spinal cord development
collagen fibril organization
lung development
negative regulation of transcription, DNA-templated
animal organ development
palate development
somite development
T-helper 17 cell lineage commitment
fibronectin fibril organization
negative regulation of T-helper 17 cell lineage commitment
positive regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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