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Invitrogen
AFG3L2 Polyclonal Antibody
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FIGURE: 1 / 2
AFG3L2 Antibody (PA5-48533) in IHC (P)
Immunohistochemistry analysis of AFG3L2 in formalin fixed and paraffin embedded human cerebellum tissue. Samples were incubated with AFG3L2 polyclonal antibody (Product # PA5-48533) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-48533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human AFG3L2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with bovine and mouse based on sequence homology.
Target Information
AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AFG3 ATPase family gene 3-like 2; AFG3 ATPase family member 3-like 2; AFG3 like AAA ATPase 2; AFG3-like protein 2; ATPase family gene 3, yeast; FLJ25993; paraplegin-like protein
Gene Aliases: OPA12; SCA28; SPAX5
UniProt ID: (Human) Q9Y4W6
Entrez Gene ID: (Human) 10939
proteolysis
axonogenesis
protein processing
protein autoprocessing
protein catabolic process
membrane protein proteolysis
mitochondrial protein processing
calcium ion transmembrane import into mitochondrion
mitochondrial calcium ion homeostasis
protein maturation
cellular response to glutathione
regulation of calcium import into the mitochondrion
mitochondrial protein quality control
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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