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Invitrogen
CDKN2B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-49749
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human p15 INK antibody.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total CDKN2B protein.
Target Information
The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDK inhibitory protein; CDK4B inhibitor; CDKN2B; Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinases 4 and 6 binding protein; Ink4; MTS-2; multiple tumor suppressor 2; p10; p14-INK4b; p14_CDK inhibitor; p14_INK4B; p15; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4b; p15Ink4b; cell cycle inhibitor; unnamed protein product
Gene Aliases: CDK4I; INK4B; MTS2; P15; p15(INK4b); p15INK4b; TP15
UniProt ID: (Human) P42772, (Mouse) P55271, (Rat) P55272
Entrez Gene ID: (Human) 1030, (Mouse) 12579, (Rat) 25164
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
protein kinase binding
p53 binding
SUMO transferase activity
NF-kappaB binding
ligase inhibitor activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
disordered domain specific binding
ubiquitin ligase inhibitor activity
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
megakaryocyte differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
cellular response to nutrient
negative regulation of epithelial cell proliferation
regulation of G0 to G1 transition
cellular response to cell-matrix adhesion
cellular senescence
regulation of G1/S transition of mitotic cell cycle
negative regulation of G1/S transition of mitotic cell cycle
spleen development
negative regulation of glial cell proliferation
negative regulation of cell cycle G1/S phase transition
liver development
positive regulation of epithelial cell differentiation
response to cytokine
cellular response to transforming growth factor beta stimulus
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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