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Invitrogen
SRGAP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50888
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human SLIT-ROBO Rho GTPase activating protein 2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total SRGAP2 protein.
Target Information
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FBP-27; formin binding protein 2; formin-binding protein 2; formin-binding protein 27; rho GTPase-activating protein 34; SLIT-ROBO GAP2; srGAP2; unnamed protein product
Gene Aliases: 9930124L22Rik; ARHGAP34; FBP2; FNBP2; RGD1566016; SRGAP2A; srGAP3
UniProt ID: (Human) O75044, (Mouse) Q91Z67, (Rat) D4A208
Entrez Gene ID: (Human) 23380, (Mouse) 14270, (Rat) 360840
lamellipodium assembly involved in ameboidal cell migration
signal transduction
nervous system development
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
regulation of cell migration
negative regulation of cell migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
regulation of synapse assembly
dendritic spine development
excitatory synapse assembly
inhibitory synapse assembly
negative regulation of neuron migration
regulation of small GTPase mediated signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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