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Invitrogen
CYP4F2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-53117
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CYP4F2. Recombinant protein control fragment (Product #RP-90565).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRNWFWGHQG MVNPTEEGMR VLTQLVATYP QGFKVWMGPI SPLLSLCHPD
Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 70%.
Target Information
CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; arachidonic acid omega-hydroxylase; CYPIVF2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; docosahexaenoic acid omega-hydroxylase; leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2; unnamed protein product
Gene Aliases: CPF2
UniProt ID: (Human) P78329
Entrez Gene ID: (Human) 8529
monooxygenase activity
iron ion binding
protein binding
arachidonic acid epoxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
alkane 1-monooxygenase activity
heme binding
leukotriene-B4 20-monooxygenase activity
arachidonic acid omega-hydroxylase activity
alpha-tocopherol omega-hydroxylase activity
20-hydroxy-leukotriene B4 omega oxidase activity
20-aldehyde-leukotriene B4 20-monooxygenase activity
long-chain fatty acid omega-hydroxylase activity
fatty acid omega-hydroxylase activity
very long-chain fatty acid omega-hydroxylase activity
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
renal water homeostasis
pressure natriuresis
icosanoid metabolic process
leukotriene metabolic process
xenobiotic metabolic process
blood coagulation
regulation of blood pressure
fatty acid omega-oxidation
arachidonic acid metabolic process
epoxygenase P450 pathway
negative regulation of icosanoid secretion
positive regulation of icosanoid secretion
leukotriene B4 catabolic process
vitamin E metabolic process
menaquinone catabolic process
phylloquinone catabolic process
vitamin K catabolic process
sodium ion homeostasis
omega-hydroxylase P450 pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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